Outcome Measures in Lupus Nephritis Trials
Overview
In partnership with the Lupus Nephritis Trial Network, a Kidney Health Initiative working group analyzed existing data to test for clear, valid endpoints for lupus nephritis trials. The working group contacted pharmaceutical companies that have completed trials in lupus nephritis to discuss the inclusion of their data in this project. Recognizing the value of including physicians treating these patients, the working group recruited global cohort sites to participate in the project.
Upon completion of the data analysis, the working group recommended a core set of outcome measures, biomarkers, surrogate markers, and clearly defined terms that should be incorporated into all future lupus nephritis trials. Developing these measures will make it much more feasible for companies to invest in the research necessary to improve treatments for patients with this serious disease.