This project is a collaboration between the National Kidney Foundation (NKF), Kidney Health Initiative, and the Food and Drug Administration (FDA)’s Center for Biologics Evaluation and Research. The goal of this project is to develop a patient-focused educational document explaining the fundamentals of kidney xenotransplantation. It builds on previous projects from all three organizations that identified information needs for patients considering clinical trials for kidney xenotransplantation. The FAQ translates complex concepts into clear, plain language for patients, families, and care partners. Organized around common patient questions, it will function as a living resource with updates made as evidence, clinical guidance, or policy shifts occur.